MVP CLIA Kit for Human(Homo sapiens) | EIAab.comMVP CLIA Kit for Human(Homo sapiens)

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MVP (Gene name),

Major vault protein (Protein name ), MVP_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MVP(LRP);

Protein name:

Major vault protein(MVP);

Alternative:

Lung resistance-related protein;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs). Interacts with TEP1. Interacts with PTEN and activated MAPK1. The phosphorylated protein interacts with the SH2 domains of PTPN11 and SRC. Interacts with APEX1. May interact with ZNF540.

Function:

Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

Subcellular Location:

Cytoplasm Nucleus nuclear pore complex 5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment.

Protein Attributes:

Sequence length:

893

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

893:

MGPEGQPLGR | RVASGPSPGE | GISPQSAQAP | QAPGDNHVVP | VLR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:9961

MIM:

605088

Pfam:

PF11978

String:

Q14764

UniGene:

Hs.632177

STRING:

9606.ENSP00000349977

SMR:

Q14764

Uniprot:

Q14764

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ELISA Kit for Human MVP

Cat.:

E1071h

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Packing:

96T

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ELISA Kit for Human MVP

Cat.:

E1071m

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96T

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ELISA Kit for Human MVP

Cat.:

E1071b

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96T

ELISA Kit for Human MVP

Cat.:

E1071r

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96T

ELISA Kit for Human MVP

Cat.:

E1071c

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96T

CLIA Kit for Human MVP

Cat.:

U1071b

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Packing:

96T

CLIA Kit for Human MVP

Cat.:

U1071r

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96T

CLIA Kit for Human MVP

Cat.:

U1071h

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Manual:

Looking for manual.

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Packing:

96T

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CLIA Kit for Human MVP

Cat.:

U1071c

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Packing:

96T

CLIA Kit for Human MVP

Cat.:

U1071m

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Packing:

96T

Polyclonal Antibody for Human MVP

Cat.:

P1071Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human MVP

Cat.:

P1071Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human MVP

Cat.:

P1071Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human MVP

Monoclonal Antibody for Human MVP

Protein for Human MVP

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"The drug resistance-related protein LRP is the human major vault protein."
Scheffer G.L. , Wijngaard P.L.J. , Flens M.J. , Izquierdo M.A. , Slovak M.L. , Pinedo H.M. , Meijer C.J.L.M. , Clevers H.C. , Scheper R.J.
Nat. Med.1:578-582(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

Scheffer G.L.
Submitted (2002-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO C-TERMINUS
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Eye.
4.

"Cloning and initial analysis of the human multidrug resistance-related MVP/LRP gene promoter."
Lange C. , Walther W. , Schwabe H. , Stein U.
Biochem. Biophys. Res. Commun.278:125-133(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-169
5.

"A small upstream open reading frame causes inhibition of human major vault protein expression from a ubiquitous mRNA splice variant."
Holzmann K. , Ambrosch I. , Elbling L. , Micksche M. , Berger W.
FEBS Lett.494:99-104(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 1-65
tissue: Lung cancer.
6.

Quadroni M. , Potts A. , Barblan J. , Bienvenut W.V.
Submitted (2005-01) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-9; 68-82 AND 462-474;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Melanoma.
7.

"Vaults and telomerase share a common subunit, TEP1."
Kickhoefer V.A. , Stephen A.G. , Harrington L. , Robinson M.O. , Rome L.H.
J. Biol. Chem.274:32712-32717(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH TEP1
8.

"PTEN associates with the vault particles in HeLa cells."
Yu Z. , Fotouhi-Ardakani N. , Wu L. , Maoui M. , Wang S. , Banville D. , Shen S.-H.
J. Biol. Chem.277:40247-40252(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTEN
9.

"The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling."
Kolli S. , Zito C.I. , Mossink M.H. , Wiemer E.A.C. , Bennett A.M.
J. Biol. Chem.279:29374-29385(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYROSINE RESIDUES;IDENTIFICATION BY MASS SPECTROMETRY;INTERACTION WITH PTPN11;SUBCELLULAR LOCATION;FUNCTION
10.

"A novel human zinc finger protein ZNF540 interacts with MVP and inhibits transcriptional activities of the ERK signal pathway."
Xiang Z. , Yuan W. , Luo N. , Wang Y. , Tan K. , Deng Y. , Zhou X. , Zhu C. , Li Y. , Liu M. , Wu X. , Li Y.
Biochem. Biophys. Res. Commun.347:288-296(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZNF540
11.

"Crosstalk between Src and major vault protein in epidermal growth factor-dependent cell signalling."
Kim E. , Lee S. , Mian M.F. , Yun S.U. , Song M. , Yi K.-S. , Ryu S.H. , Suh P.-G.
FEBS J.273:793-804(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SRC;TYROSINE PHOSPHORYLATION;SUBCELLULAR LOCATION;IDENTIFICATION BY MASS SPECTROMETRY
12.

"The major vault protein is responsive to and interferes with interferon-gamma-mediated STAT1 signals."
Steiner E. , Holzmann K. , Pirker C. , Elbling L. , Micksche M. , Sutterluety H. , Berger W.
J. Cell Sci.119:459-469(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;FUNCTION
13.

"Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1."
Chattopadhyay R. , Das S. , Maiti A.K. , Boldogh I. , Xie J. , Hazra T.K. , Kohno K. , Mitra S. , Bhakat K.K.
Mol. Cell. Biol.28:7066-7080(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH APEX1
14.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
15.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.

"Solution structure of a two-repeat fragment of major vault protein."
Kozlov G. , Vavelyuk O. , Minailiuc O. , Banville D. , Gehring K. , Ekiel I.
J. Mol. Biol.356:444-452(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 113-221;INTERACTION WITH PARP4

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